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In the domains of EE, the research achievements of EE research laboratories have translated in the creation of important spin-offs
| Name | Year | Web | Field | Research Lab | Faculty |
| Gait Up | 2013 | https://gaitup.com/ | MedTech | LMAM | Prof. Aminian |
| Fastree 3D Imagers | 2013 | https://fastree3d.com/ | Electrical-electronics | AQUA | Prof. Charbon (EE/MT) |
| SmartCardia | 2013 | http://www.smartcardia.com | Medtech | ESL | Prof. Atienza |
| Imperix | 2013 | https://imperix.ch/ | Energy-environment | LEI | Prof. Rufer |
| Actlight | 2014 | https://act-light.com/ | Sensors | GR-KA | Prof. Kayal |
| Xsensio | 2014 | https://xsensio.com/ | Micro-nanotech | NANOLAB | Prof. Ionescu |
| Hidacs Acoustic Technologies | 2016 | http://hidacs.com | Electrical-electronics | LEMA | Prof. Mosig |
| Genomsys | 2016 | https://genomsys.com/ | Medtech | MM | Prof. Mattavelli |
| Panoptic | 2016 | Sensors | LTS2/LSM | Prof. Vandergheynst / Prof. Leblebici | |
| Ligentec | 2016 | https://www.ligentec.com/ | Silicon photonics | LPQM | Prof. Kippenberg |
| Aurora’s Grid | 2016 | http://www.aurorasgrid.com/ | Electrical-electronics | DESL | Prof. Paolone |
| Zaphiro Technologies | 2017 | http://www.zaphiro.ch | Sensing devices | DESL | Prof. Paolone |
| PN Solutions | 2017 | http://www.pnsolutions.ch | Electronics | GR-KA | Prof. Kayal |
| Aesyra | 2017 | Sensors | CLSE | Prof. Guiducci | |
| Intuitive therapeutics | 2018 | http://www.intuitivetherapeutics.com | Medical imaging | LTS5 | Prof. Thiran |
| Archinisis | 2018 | https://www.archinisis.ch | Electronic technology | LMAM | Prof. Aminian |
| GridSteer | 2018 | https://www.gridsteer.ch | Power grid control | DESL | Prof. Paolone |
| MicroR | 2018 | https://www.microrsystems.com/ | Optical technology | LPQM | Prof. Kippenberg |